Tocofersolan

Tocofersolan is a nonionic surfactant and derivative of vitamin E. It has a critical micelle concentration (CMC) of 0.02 mM at room temperature. Tocofersolan inhibits P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), substrate-induced ATPase activity in cell-free assays (IC50s = 0.4-3.25 µM). It reverses locomotor deficits induced by the polycyclic aromatic hydrocarbon benzo[a]pyrene in zebrafish larvae when used at a concentration of 1 µM. Intravenous administration of nanocrystals containing tocofersolan (50 mg/kg) and paclitaxel (Cay-10461) reduces tumor growth in an NCI/ADR-RES ovarian cancer mouse xenograft model. Liposomes containing tocofersolan and DOTMA (Cay-25926) and encapsulating anti-miR-21 accumulate in the liver, lung, and spleen and decrease lung fibrosis in a mouse model of pulmonary fibrosis induced by the glycopeptide antitumor antibiotic bleomycin (Cay-13877).Formal Name: alpha-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-omega-hydroxy-poly(oxy-1,2-ethanediyl). CAS Number: 9002-96-4. Synonyms: Tocophersolan, D-alpha-Tocopheryl Polyethylene Glycol Succinate, TPGS, TPGS 1000, VE-TPGS, Vitamin E TPGS. Molecular Formula: (C2H4O)nC33H54O5. Formula Weight: 574.8. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 205, 284 nm. SMILES: O=C(CCC(OCCO)=O)OC1=C(C)C2=C(OC(CC2)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C1C.