Ticarcillin disodium

Description: Ticarcillin disodium (Ticarpen) is the disodium salt form of ticarcillin, a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Similar to carbenicillin in action, ticarcillin inactivates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis. Target: Antibacterial, Antibiotic. Smiles: [Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3cccs3)C(=O)N2[C@H]1C([O-])=O. References: Webb D, et al. Arch Intern Med. 1978 Nov,138(11):1618-20.