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Description: Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 µM). It inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Target: Proton pump, Autophagy, Antibacterial. Smiles: [Br-].CCCCCCCCCC CCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1. References: Chan, C., Prudom, C., Raines, S., Charkhzarrin, S., Melman, S., & De Haro, L. et al. (2012). Inhibitors of V-ATPase Proton Transport Reveal Uncoupling Functions of Tether Linking Cytosolic and Membrane Domains of V 0 Subunit a (Vph1p). Journal Of Biological Chemistry, 287(13), 10236-10250. doi: 10.1074/jbc.m111.321133
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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