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Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 µM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of beta-globin pre-mRNA at 1 µM in vitro. At 10 µM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.Formal Name: 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone. CAS Number: 300801-52-9. Molecular Formula: C13H15NO2S. Formula Weight: 249.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 30 mg/ml, Ethanol: 15 mg/ml. lambdamax: 215, 250, 362 nm. SMILES: CCN(C1=CC(OC)=CC=C1S/2)C2=C\C(C)=O. InChi Code: InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-. InChi Key: BGVLELSCIHASRV-QPEQYQDCSA-N.
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