TG003

TG003
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10398-1 1 mg -

1 - 10 business days

23.00€
Cay10398-5 5 mg -

1 - 10 business days

102.00€
Cay10398-10 10 mg -

1 - 10 business days

180.00€
Cay10398-25 25 mg -

1 - 10 business days

394.00€
 
Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich... more
Product information "TG003"
Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 µM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of beta-globin pre-mRNA at 1 µM in vitro. At 10 µM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.
Keywords: 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
Supplier: Cayman Chemical
Supplier-Nr: 10398-1

Properties

Application: Cdc2 kinase inhibitor
MW: 249.3 D
Formula: C13H15NO2S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 300801-52-9| Search using CAS
KEGG ID : K02087 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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