Tetrodotoxin (citrate free)

Tetrodotoxin (citrate free)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14963-1 1 mg -

6 - 10 business days*

316.00€
 
TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current... more
Product information "Tetrodotoxin (citrate free)"
TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials. It inhibits the NaV current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley's classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the NaV current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain.Formal Name: (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol. CAS Number: 4368-28-9. Synonyms: Araregai Toxin, Maculotoxin, Tectin, TTX. Molecular Formula: C11H17N3O8. Formula Weight: 319.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acidic Buffer (pH 4.8): 3 mM. SMILES: NC1=N[C@H](O)[C@@]2([H])[C@]3([H])[C@](CO)(O)[C@]([H])([C@@]4([H])O)O[C@@](O)(O3)[C@@H](O)[C@@]24N1. InChi Code: InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1. InChi Key: CFMYXEVWODSLAX-QOZOJKKESA-N.
Keywords: Araregai Toxin, Maculotoxin, Tectin, TTX, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol
Supplier: Cayman Chemical
Supplier-Nr: 14963

Properties

Application: NaV channel blocking
MW: 319.3 D
Formula: C11H17N3O8
Purity: >98%
Format: Solid

Database Information

CAS : 4368-28-9| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H310, H330
P Phrases: P260, P262, P264, P270, P271, P280, P284, P320, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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