Tetrachlorohydroquinone

Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 µM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.Formal Name: 2,3,5,6-tetrachloro-1,4-benzenediol. CAS Number: 87-87-6. Synonyms: NSC 4858, NSC 100888, TCHQ. Molecular Formula: C6H2Cl4O2. Formula Weight: 247.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 309 nm. SMILES: OC1=C(Cl)C(Cl)=C(O)C(Cl)=C1Cl. InChi Code: InChI=1S/C6H2Cl4O2/c7-1-2(8)6(12)4(10)3(9)5(1)11/h11-12H. InChi Key: STOSPPMGXZPHKP-UHFFFAOYSA-N.