Terbinafine-d3 (hydrochloride)

Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine (Cay-10011619) by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 µg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 µM, respectively). Terbinafine (90-120 µM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs). Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.Formal Name: N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine, monohydrochloride. CAS Number: 1310012-15-7. Molecular Formula: C21H22D3N . HCl. Formula Weight: 330.9. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: 14 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml. SMILES: CC(C)(C)C#C/C=C/CN(C([2H])([2H])[2H])CC1=CC=CC2=CC=CC=C21.Cl. InChi Code: InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19,/h5-7,9-14H,16-17H2,1-4H3,1H/b9-5+,/i4D3,. InChi Key: BWMISRWJRUSYEX-YOVIYTQZSA-N.