Terazosin (hydrochloride)

Terazosin is a potent and selective alpha1-adrenergic receptor (alpha1-AR) antagonist (Kis = 3.28, 0.68, and 1.09 for alpha1A-, alpha1B- and alpha1D-ARs, respectively). It is selective for alpha1- over alpha2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively). Terazosin (0.1-30 mg/kg) decreases blood pressure in spontaneously hypertensive rats. It also decreases blood pressure in anesthetized dogs. Formulations containing terazosin are used to treat hypertension and benign prostatic hyperplasia.Formal Name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-methanone, monohydrochloride. CAS Number: 63074-08-8. Molecular Formula: C19H25N5O4 . HCl. Formula Weight: 423.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml. lambdamax: 214, 247 nm. SMILES: COC1=C(OC)C=C(C(N)=NC(N2CCN(C(C3CCCO3)=O)CC2)=N4)C4=C1.Cl. InChi Code: InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14,/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22),1H. InChi Key: IWSWDOUXSCRCKW-UHFFFAOYSA-N.