Tenovin-6 (hydrochloride)

The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 µM, respectively.Formal Name: N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide, monohydrochloride. CAS Number: 1011301-29-3. Molecular Formula: C25H34N4O2S . HCl. Formula Weight: 491.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 274 nm. SMILES: O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2.Cl. InChi Code: InChI=1S/C25H34N4O2S.ClH/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5,/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32),1H. InChi Key: UBNCTIDXQDCEPI-UHFFFAOYSA-N.