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Description: Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions. Target: Apoptosis, Autophagy, DNA/RNA Synthesis, DNA Alkylator/Crosslinker. Smiles: CN1N=NC2=C(N=CN2C1=O)C(N)=O. References: Mhaidat NM, et al. Temozolomide induces senescence but not apoptosis in human melanoma cells. Br J Cancer. 2007 Nov 5,97(9):1225-33.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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