TCL065

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-TCL-01227-10mg	10 mg	-	-	-	5 - 10 business days*		-
TGM-TCL-01227-50mg	50 mg	-	-	-	5 - 10 business days*		-

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Description: TCL065, an ionizable cationic lipid (pKa = 6.3), is utilized in the creation of... more

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Product information "TCL065"

Description: TCL065, an ionizable cationic lipid (pKa = 6.3), is utilized in the creation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) both in vitro and in vivo. When LNPs with TCL065 encapsulate sgRNA targeting the donor site of dystrophin exon 45, along with those targeting the splicing acceptor site of dystrophin exon 45, dystrophin expression is restored in myoblasts derived from induced-pluripotent stem (iPS) cells from Duchenne muscular dystrophy (DMD) patients. Additionally, TCL065-containing LNPs encapsulating mRNA encoding Cas9 nuclease, combined with those containing sgRNA targeting the Rosa26 locus, have been applied for CRISPR-mediated gene editing in mouse gastrocnemius muscle. Target: Others. Smiles: O=C(OCC(COC(=O)CC(CCCCC)CCCCC)(COC(=O)CC(CCCCC)CCCCC)COC(=O)CC(CCCCC)CCCCC)CCCCN(C)C

Supplier:	TargetMol
Supplier-Nr:	TCL-01227

Properties

MW:	852.32 D
Formula:	C51H97NO8

Database Information

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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