TC4

A synthetic peptide and tetra-agonist of GLP-1R, GCGR, GIPR, and Y2 receptor, cAMP-biased GLP-1R agonist that selectivity induces cAMP accumulation over beta-arrestin-2 recruitment, induces cAMP accumulation in HEK293T cells expressing human GLP-1R, GCGR, or GIPR (EC50s = 31, 81, and 0.98 pM, respectively), induces intracellular Ca2+ release in the HEK293T cells expressing Y2 receptor (EC50 = 1,100 pM). SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(NC(C)(C)C(N[C@H](C(NCC(N[C@]([H])(C(N[C@@H](CC2=CC=CC=C2)C(N[C@]([H])(C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@H](C(N[C@]([H])(C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@]([H])(C(N[C@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N6CCC[C@H]6C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC7=CN=CN7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@H](C(N[C@H](C(N[C@@H](CC9=CNC%10=C9C=CC=C%10)C(N[C@H](C(N[C@]([H])(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)CC(C)C)=O)=O)CC(N)=O)=O)C(C)C)=O)=O)=O)CCCNC(N)=N)=O)=O)CO)=O)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)=O)=O)CCC(N)=O)=O)=O)CCCCNC(CCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC(C)C)=O)[C@@H](C)CC)=O)CO)=O)=O)=O)CO)=O)[C@H](O)C)=O)=O)[C@H](O)C)=O)=O)CCC(N)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C277H423N69O78.C2HF3O2/c1-27-151(17)225(266(415)317-185(97-103-221(373)374)244(393)325-194(126-163-76-86-170(355)87-77-163)250(399)322-190(118-146(7)8)247(396)320-188(116-144(3)4)246(395)314-181(96-102-220(371)372)235(384)302-136-215(365)301-138-218(368)346-112-57-69-207(346)264(413)336-204(139-347)261(410)324-189(117-145(5)6)245(394)312-179(67-55-108-298-275(288)289)242(391)329-200(130-167-135-292-143-304-167)253(402)327-197(128-165-80-90-172(357)91-81-165)258(407)340-224(150(15)16)265(414)334-201(131-211(282)361)254(403)328-199(129-166-134-300-175-63-50-49-62-173(166)175)252(401)323-193(121-149(13)14)257(406)343-228(157(23)351)269(418)316-180(68-56-109-299-276(290)291)240(389)315-184(94-100-210(281)360)243(392)311-178(66-54-107-297-274(286)287)241(390)318-187(230(283)379)123-162-74-84-169(354)85-75-162)341-259(408)196(124-159-58-43-41-44-59-159)319-233(382)154(20)305-231(380)153(19)306-238(387)183(93-99-209(280)359)309-232(381)155(21)307-237(386)176(64-51-52-105-293-213(363)104-110-294-217(367)142-424-115-114-423-113-111-295-212(362)101-95-186(271(420)421)308-214(364)70-47-39-37-35-33-31-29-30-32-34-36-38-40-48-71-219(369)370)310-239(388)177(65-53-106-296-273(284)285)313-255(404)202(132-222(375)376)330-248(397)191(119-147(9)10)321-249(398)192(120-148(11)12)332-267(416)226(152(18)28-2)342-263(412)206(141-349)335-251(400)195(127-164-78-88-171(356)89-79-164)326-256(405)203(133-223(377)378)331-262(411)205(140-348)337-270(419)229(158(24)352)344-260(409)198(125-160-60-45-42-46-61-160)333-268(417)227(156(22)350)339-216(366)137-303-236(385)182(92-98-208(279)358)338-272(422)277(25,26)345-234(383)174(278)122-161-72-82-168(353)83-73-161,3-2(4,5)1(6)7/h41-46,49-50,58-63,72-91,134-135,143-158,174,176-207,224-229,300,347-357H,27-40,47-48,51-57,64-71,92-133,136-142,278H2,1-26H3,(H2,279,358)(H2,280,359)(H2,281,360)(H2,282,361)(H2,283,379)(H,292,304)(H,293,363)(H,294,367)(H,295,362)(H,301,365)(H,302,384)(H,303,385)(H,305,380)(H,306,387)(H,307,386)(H,308,364)(H,309,381)(H,. InChi Key: IWWXLHMVFAIXSN-VAXUNXTASA-N