(±)-Taxifolin

(±)-Taxifolin is a flavonoid that has been found in M. butyracea and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in cell-free assays. (±)-Taxifolin is cytotoxic to HCT116 cells (IC50 = 63.42 µM). It inhibits HMG-CoA reductase activity and cholesterol synthesis in HepG2 cells by 47 and 86%, respectively, when used at a concentration of 200 µM. In vivo, (±)-taxifolin reduces carrageenan-induced paw edema in rats (ED50 = 12.9 mg/kg).Formal Name: (2R,3R)-rel-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one. CAS Number: 24198-97-8. Synonyms: (±)-Dihydroquercetin. Molecular Formula: C15H12O7. Formula Weight: 304.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 3 mg/ml. lambdamax: 290 nm. SMILES: OC1=CC(O)=C(C([C@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)=O)C3=C1. InChi Code: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1. InChi Key: CXQWRCVTCMQVQX-LSDHHAIUSA-N.