tau-Fluvalinate

Description: tau-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of tau-fluvalinate (2 µl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos , and chlorothalonil does not affect honeybee queen mass, egg-laying patterns, or the mass of daughter worker bees at emergence.2Formulations containing tau-fluvalinate have been used to control Varroa mites in beehives. Target: Others. Smiles: C(OC([C@H](NC1=C(Cl)C=C(C(F)(F)F)C=C1)[C@H](C)C)=O)(C#N)C2=CC(OC3=CC=CC=C3)=CC=C2. References: Gosselin-Badaroudine, P., and Chahine, M.Biophysical characterization of the Varroa destructor NaV1 sodium channel and its affinity for tau-fluvalinate insecticideFASEB J.31(7)3066-3071(2017)