Tasimelteon

Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors (Kis = 0.304 and 0.069 nM, respectively, in NIH3T3 cells expressing the recombinant human receptors) over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.Formal Name: N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-propanamide. CAS Number: 609799-22-6. Synonyms: BMS 214778. Molecular Formula: C15H19NO2. Formula Weight: 245.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 287 nm. SMILES: O=C(CC)NC[C@@H]1C[C@H]1C2=C3C(OCC3)=CC=C2. InChi Code: InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1. InChi Key: PTOIAAWZLUQTIO-GXFFZTMASA-N.