Tanshinone IIA sulfonate (sodium salt)

Tanshinone IIA sulfonate is a derivative of tanshinone IIA (Cay-14323) and has immunomodulatory activities. It reduces secretion of IL-6 and IL-8 induced by cigarette smoke extract (CSE) and prevents CSE-induced decreases in cystic fibrosis transmembrane conductance regulator (CFTR) levels in 16HBE human bronchial epithelial cells. Inhalation of tanshinone IIA sulfonate (5 mg/kg) reduces lung function decline, mucus production, bronchial collagen deposition, and airspace enlargement in a mouse model of CS-induced chronic obstructive pulmonary disease (COPD). Tanshinone IIA sulfonate (15 mg/kg) reduces myocardial necrosis and production of TNF-alpha and IL-6 in a mouse model of sepsis induced by cecal ligation and puncture (CLP). It reduces the number of peripheral CD4+ and CD8+ T cells and prolongs allogeneic skin graft survival in a rat transplantation model.Formal Name: 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-phenanthro[1,2-b]furan-2-sulfonic acid, monosodium salt. CAS Number: 69659-80-9. Synonyms: Sodium Tanshinone IIA sulfonate, Sulfotanshinone sodium II-A. Molecular Formula: C19H17O6S . Na. Formula Weight: 396.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 226, 254, 272, 280 nm. SMILES: CC1=C(S([O-])(=O)=O)OC(C2=C3C4=C(C=C2)C(C)(C)CCC4)=C1C(C3=O)=O.[Na+]. InChi Code: InChI=1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24,/h6-7H,4-5,8H2,1-3H3,(H,22,23,24),/q,+1/p-1. InChi Key: AZEZEAABTDXEHR-UHFFFAOYSA-M.