Talatisamine

Talatisamine is a diterpene alkaloid originally isolated from A. talassicum and has diverse biological activities. It blocks delayed rectifier potassium (IK) current in rat hippocampal neurons (IC50 = 146 µM). Talatisamine reduces increases in IK current and cytotoxicity in primary rat cortical neurons induced by amyloid-beta (1-40) (Abeta40, Cay-21617). It inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 µM). Talatisamine exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm).Formal Name: 20-ethyl-1alpha,16beta-dimethoxy-4-(methoxymethyl)-aconitane-8,14alpha-diol. CAS Number: 20501-56-8. Molecular Formula: C24H39NO5. Formula Weight: 421.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1mg/mL, DMSO: 2 mg/mL, Ethanol: 10mg/mL. SMILES: [H][C@]1(C2)C([C@@H](OC)CC[C@]34COC)(C5N(CC)C4)[C@]3([H])CC5[C@]6(O)[C@@]1([H])[C@@H](O)[C@@]2([H])[C@@H](OC)C6. InChi Code: InChI=1S/C24H39NO5/c1-5-25-11-22(12-28-2)7-6-18(30-4)24-14-8-13-16(29-3)10-23(27,19(14)20(13)26)15(21(24)25)9-17(22)24/h13-21,26-27H,5-12H2,1-4H3/t13-,14-,15?,16+,17-,18+,19-,20+,21?,22+,23+,24?/m1/s1. InChi Key: BDCURAWBZJMFIK-FIIQKEKKSA-N. Origin: Plant/Aconitum tenuifolia.