TACA

TACA is an agonist of the rho1 subunit-containing homomeric GABAA receptor, previously known as the GABAC receptor. It binds to homomeric GABAA receptors (Ki = 0.36 µM) and induces chloride currents in X. laevis oocytes expressing the human receptor (EC50 = 0.53 µM). TACA (20 mg/kg) inhibits anxiolytic-like activity induced by the flavonoid quercetin (Cay-10005169) in mice.Formal Name: 4-amino-2E-butenoic acid. CAS Number: 38090-53-8. Synonyms: trans-4-Aminocrotonic Acid. Molecular Formula: C4H7NO2. Formula Weight: 101.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: slightly soluble, Water: slightly soluble. SMILES: OC(/C=C/CN)=O. InChi Code: InChI=1S/C4H7NO2/c5-3-1-2-4(6)7/h1-2H,3,5H2,(H,6,7)/b2-1+. InChi Key: FMKJUUQOYOHLTF-OWOJBTEDSA-N.