T16A(inh)-A01

Transmembrane protein 16A (TMEM16A, also known as anoctamin-1) is a calcium-activated chloride channel (CaCC) with roles in transepithelial anion transport and smooth muscle contraction. T16A(inh)-A01 is an aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. Its inhibitory effects are independent of voltage and do not prolong the rate of TMEM16A current deactivation. T16A(inh)-A01 blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels. It also inhibits the proliferation of pancreatic cancer and squamous carcinoma cells in culture.Formal Name: 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide. CAS Number: 552309-42-9. Molecular Formula: C19H20N4O3S2. Formula Weight: 416.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2), (1:7): 0.1 mg/ml, DMSO: 5 mg/ml. lambdamax: 246, 274 nm. SMILES: COC1=CC=C(C2=CSC(NC(CSC(NC(C)=C3CC)=NC3=O)=O)=N2)C=C1. InChi Code: InChI=1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24). InChi Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N.