Sydowinin B

Sydowinin B is a xanthone polyketide that has been found in A. sydowii and has immunosuppressant activity. It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 µg/ml, respectively). Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B (Cay-11328) and N-Formyl-Met-Leu-Phe (fMLF, Cay-21495) with IC50 values of 21.2 and 12.62 µM, respectively.Formal Name: 2,8-dihydroxy-6-(hydroxymethyl)-9-oxo-9H-xanthene-1-carboxylic acid, methyl ester. CAS Number: 58450-00-3. Synonyms: MS-347b. Molecular Formula: C16H12O7. Formula Weight: 316.3. Purity: >95%. Formulation: (Request formulation change), A solid. SMILES: O=C(C(C(O)=CC=C1OC2=CC(CO)=CC(O)=C23)=C1C3=O)OC. InChi Code: InChI=1S/C16H12O7/c1-22-16(21)13-8(18)2-3-10-14(13)15(20)12-9(19)4-7(6-17)5-11(12)23-10/h2-5,17-19H,6H2,1H3. InChi Key: SSBSKLSIZKVBFF-UHFFFAOYSA-N. Origin: Fungus/Aspergillus sydowii.