Sunitinib (malate)

Sunitinib (malate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13159-1 1 mg -

6 - 10 business days*

38.00€
Cay13159-5 5 mg -

6 - 10 business days*

73.00€
Cay13159-10 10 mg -

6 - 10 business days*

119.00€
Cay13159-50 50 mg -

6 - 10 business days*

173.00€
 
Sunitinib is a small molecule inhibitor of receptor tyrosine kinases, including FLK1 (Ki = 9 nM),... more
Product information "Sunitinib (malate)"
Sunitinib is a small molecule inhibitor of receptor tyrosine kinases, including FLK1 (Ki = 9 nM), PDGFRbeta (Ki = 8 nM), and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl, and Src. Sunitinib inhibits VEGF-dependent FLK1 and PDGF-dependent PDGFRbeta phosphorylation (IC50s = 10 and 10 nM, respectively) as well as phosphorylation of FLT3 and FLT3 carrying the activating internal tandem duplication mutation (FLT3-ITD, IC50s = 250 and 50 nM, respectively). It decreases VEGF- and FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs, IC50s = 30 and 700 nM, respectively) and reduces tumor growth in a variety of mouse xenograft models when administered at doses ranging from 20 to 80 mg/kg per day. Formulations containing sunitinib have been used in the treatment of gastrointestinal stromal tumors and metastatic renal cell carcinoma. Formal Name: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, (2S)-hydroxy-butanedioic acid. CAS Number: 341031-54-7. Synonyms: SU11248. Molecular Formula: C22H27FN4O2 . C4H6O5. Formula Weight: 532.6. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 267, 427 nm. SMILES: CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2\C(=O)Nc3ccc(F)cc/23)c1COC(=O)C[C@H](O)C(=O)O. InChi Code: InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28,5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28),2,5H,1H2,(H,6,7)(H,8,9)/b17-12-,. InChi Key: LBWFXVZLPYTWQI-HBPAQXCTSA-N.
Keywords: SU11248, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, (2S)-hydroxy-butanedioic acid
Supplier: Cayman Chemical
Supplier-Nr: 13159

Properties

Application: Receptor tyrosine kinase inhibitor
MW: 532.6 D
Formula: C22H27FN4O2 . C4H6O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 341031-54-7| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H360, H372
P Phrases: P201, P202, P260, P264, P270, P280, P308+313, P314, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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