Sulindac

Description: Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway, this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Target: COX, Autophagy. Smiles: C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3. References: Yamamoto Y, et al. J Biol Chem,1999, 274(38), 27307-27314.