Sucrose octasulfate (potassium salt)

Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).Formal Name: 2,3,4,6-tetrakis(hydrogen sulfate),1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside, octapotassium salt. CAS Number: 73264-44-5. Synonyms: SOS, Sucrosofate potassium. Molecular Formula: C12H14O35S8 . 8K. Formula Weight: 1287.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 10 mg/ml. SMILES: O=S(O[C@H]1[C@H](OS(=O)([O-])=O)[C@@H](COS(=O)([O-])=O)O[C@H](O[C@]2(COS(=O)([O-])=O)O[C@H](COS(=O)([O-])=O)[C@@H](OS(=O)([O-])=O)[C@@H]2OS(=O)([O-])=O)[C@@H]1OS(=O)([O-])=O)([O-])=O.[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+]. InChi Code: InChI=1S/C12H22O35S8.8K/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18,,,,,,,,/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,2. InChi Key: XISWAUUBQBEDFB-OAHZNKFOSA-F.