Sucralfate (technical grade)

Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity. It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin (Cay-70270), or cysteamine (Cay-22193) in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions. Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.Formal Name: hexadeca-µ-hydroxytetracosahydroxy[µ8-[[1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside tetrakis(sulfato-kappaO')](8-)]]hexadeca-aluminum. CAS Number: 54182-58-0. Molecular Formula: C12H54Al16O75S8. Formula Weight: 2086.7. Formulation: (Request formulation change), A solid. Solubility: aqueous acid: slightly soluble. SMILES: O=S(OC[C@@H]1[C@@H](OS(=O)([O-][Al+3]2([OH-][Al+3]([OH-])([OH-])[OH-]2)[OH-])=O)[C@H](OS(=O)([O-][Al+3]3([OH-][Al+3]([OH-])([OH-])[OH-]3)[OH-])=O)[C@](COS(=O)([O-][Al+3]4([OH-][Al+3]([OH-])([OH-])[OH-]4)[OH-])=O)(O[C@@]5([H])O[C@H](COS(=O)([O-][Al+3]6([OH-][Al+3]([OH-])([OH-])[OH-]6)[OH-])=O)[C@@H](OS(=O)([O-][Al+3]7([OH-][Al+3]([OH-])([OH-])[OH-]7)[OH-])=O)[C@H](OS(=O)([O-][Al+3]8([OH-][Al+3]([OH-])([OH-])[OH-]8)[OH-])=O)[C@H]5OS(=O)([O-][Al+3]9([OH-][Al+3]([OH-])([OH-])[OH-]9)[OH-])=O)O1)([O-][Al+3]%10([OH-][Al+3]([OH-])([OH-])[OH-]%10)[OH-])=O. InChi Code: InChI=1S/C12H22O35S8.16Al.40H2O/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36),,,,,,,,,,,,,,,,,40*1H2/q,16*+3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,/p-48/t4-,5-,6-,7-,8+,9-,10+,11-,12+,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,/m1......................................................../s1. InChi Key: DTULOKYBGCTCFP-QRLOXDDHSA-A.