Succinylcholine (chloride hydrate)

Succinylcholine is an agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). It activates the muscle-type alpha1beta1deltaepsilon subunit-containing nAChR (EC50 = 10.8 µM in X. laevis oocytes expressing the human receptor) then induces desensitization of the receptor. It is selective for the muscle-type nAChR over alpha3beta2, alpha3beta4, alpha4beta2, or alpha7 subunit-containing neuronal nAChRs (IC50s = >100 µM). Succinylcholine (600 µg) induces neuromuscular block in isolated rat phrenic nerve-diaphragm preparations stimulated via the phrenic nerve. Formulations containing succinylcholine have been used as an adjunct to general anesthesia for its muscle relaxant properties.Formal Name: 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-ethanaminium, dichloride, dihydrate. CAS Number: 6101-15-1. Synonyms: Suxamethonium. Molecular Formula: C14H30N2O4 . 2Cl [2H2O]. Formula Weight: 397.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: O=C(CCC(OCC[N+](C)(C)C)=O)OCC[N+](C)(C)C.[Cl-].O.O.[Cl-]O=C(CCC(OCC[N+](C)(C)C)=O)OCC[N+](C)(C)C.[Cl-].O.O.[Cl-]. InChi Code: InChI=1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6,,,,/h7-12H2,1-6H3,2*1H,2*1H2/q+2,,,,/p-2. InChi Key: FFSBEIRFVXGRPR-UHFFFAOYSA-L.