Streptomycin (sulfate)

Streptomycin is an aminoglycoside antibiotic that inhibits growth of both Gram-negative (MICs = 1 and 16 µg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 µg/mL for S. pneumoniae). It inhibits growth of M. tuberculosis H37Rv (MIC = 5 µg/mL) and of susceptible strains from clinical isolates (MICs = =0.125-1 µg/mL). Streptomycin (150 mg/kg), in combination with isoniazid (Cay-20378), rifapentine (Cay-20307), and moxifloxacin (Cay-14830), administered once per week over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs of the majority of treated mice. However, after 3 months without treatment, 58% of treated mice produce a positive lung culture. Streptomycin acts by inhibiting protein synthesis in prokaryotes by binding to the 30S ribosomal subunit. It has been used, in combination with penicillin G (Cay-21615), in antibiotic cocktails to prevent bacterial growth in cell culture. Formulations containing streptomycin in combination with other antibiotics have been used to treat tuberculosis.Formal Name: O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1->4)-N1,N3-bis(aminoiminomethyl)-D-streptamine. CAS Number: 3810-74-0. Molecular Formula: C21H39N7O12 . 1.5H2SO4. Formula Weight: 728.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 13 mg/ml, DMSO: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 231 nm. SMILES: NC(N[C@@H]1[C@@H](O)[C@H](NC(N)=N)[C@](O[C@H]2[C@H](O[C@]3([H])O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3NC)[C@](C=O)(O)[C@H](C)O2)([H])[C@H](O)[C@H]1O)=N.OS(=O)(O)=O.OS(=O)(O)=O. InChi Code: InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35,3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28),3*(H2,1,2,3,4)/t2*5-,6-,7+,8-. InChi Key: QTENRWWVYAAPBI-YCRXJPFRSA-N.