Streptazolin

Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-kappaB activity when used at concentrations ranging from 60 to 130 µg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-alpha secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.Formal Name: 4-ethylidene-2aS,3S,4Z,6,7,7bS-hexahydro-3-hydroxy-1H-2-oxa-7a-azacyclopent[cd]inden-1-one. CAS Number: 80152-07-4. Synonyms: (+)-Streptazolin. Molecular Formula: C11H13NO3. Formula Weight: 207.2. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C1O[C@]([C@]2([H])C/3=CCCN21)([H])[C@@H](O)C3=C/C. InChi Code: InChI=1S/C11H13NO3/c1-2-6-7-4-3-5-12-8(7)10(9(6)13)15-11(12)14/h2,4,8-10,13H,3,5H2,1H3/b6-2-/t8-,9-,10-/m0/s1. InChi Key: OJIUACOQFBQCDF-IKXJTIOISA-N. Origin: Bacterium/Streptomyces sp..