STK16-IN-1

STK16-IN-1 is an inhibitor of the serine/threonine kinase STK16 (IC50 = 295 nM). It is selective for STK16 over mTOR, PI3Kdelta, and PI3Kgamma in an enzyme assay (IC50s = 5,560, 856, and 867 nM, respectively) and over 440 additional kinases in a KinomeScan profiling assay. It decreases the growth of MCF-7 cells (GI50 = ~10 µM) and increases the number of binucleated cells. STK16-IN-1 (2.5-5 µM) potentiates the antiproliferative effects of colchicine (Cay-9000760), paclitaxel (Cay-10461), doxorubicin (Cay-15007), and cisplatin (Cay-13119) in MCF-7 cells.Formal Name: 1-(4-fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one. CAS Number: 1223001-53-3. Molecular Formula: C17H12FN3O. Formula Weight: 293.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: FC1=CC=C(N2C(C(C=CC2=O)=CN3)=C4C3=NC=C4)C=C1C. InChi Code: InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20). InChi Key: WQNRDXHKVSKUPI-UHFFFAOYSA-N.