Stavudine

Stavudine is an inhibitor of HIV reverse transcriptase and a derivative of the nucleoside thymidine (Cay-20519). It inhibits HIV-1 replication in human peripheral blood mononuclear cells (PBMCs, EC50 = 8.8 nM). Stavudine reduces the synthesis of HIV-specific antigen in MT-4 cells when used at concentrations ranging from 0.1 to 10 µg/ml and reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml. It reduces plasma- and cell-associated viral load in macaques infected with a highly pathogenic isolate of HIV-2. Stavudine induces sustained hind paw mechanical allodynia in a rat model of antiretroviral toxic neuropathy (ATN) when administered at a dose of 75 mg/kg twice weekly for five consecutive doses for a cumulative dose of 375 mg/kg. Formulations containing stavudine, in combination with other antiretrovirals, have been used in the treatment of HIV-1 infection.Formal Name: 2',3'-didehydro-3'-deoxy-thymidine. CAS Number: 3056-17-5. Synonyms: BMY 27857, d4T, NSC 163661. Molecular Formula: C10H12N2O4. Formula Weight: 224.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 265 nm. SMILES: OC[C@H]1O[C@@H](N2C(NC(C(C)=C2)=O)=O)C=C1. InChi Code: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1. InChi Key: XNKLLVCARDGLGL-JGVFFNPUSA-N.