STAT3-IN-12

STAT3-IN-12 is an inhibitor of STAT3 (IC50 = 2. µM). It induces apoptosis in HepG2 hepatocellular carcinoma and EC109 esophageal carcinoma cells when used at concentrations of 5, 10, and 20 µM. In vivo, STAT3-IN-12 (20 and 40 mg/kg) reduces tumor volume in a HepG2 mouse xenograft model. Formal Name: 2,6-bis(3-methoxyphenyl)-1,7-dipropyl-1,7-dihydrobenzo[1,2-d:4,5-d']diimidazole. CAS Number: 2980758-31-2. Synonyms: Signal Transducer and Activator of Transcription 3-IN-12 Signal Transducer and Activator of Transcription 3 Inhibitor 12 STAT3 Inhibitor 12. Molecular Formula: C28H30N4O2. Formula Weight: 454.6. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: COC1=CC=CC(C2=NC3=C(C=C(N(C(C4=CC(OC)=CC=C4)=N5)CCC)C5=C3)N2CCC)=C1. InChi Code: InChI=1S/C28H30N4O2/c1-5-13-31-25-18-26-24(17-23(25)29-27(31)19-9-7-11-21(15-19)33-3)30-28(32(26)14-6-2)20-10-8-12-22(16-20)34-4/h7-12,15-18H,5-6,13-14H2,1-4H3. InChi Key: BWCIDDGTJILXKX-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.