Stachybotrylactam

Stachybotrylactam is a spirodihydrobenzofuranlactam mycotoxin originally isolated from Stachybotrys with antiviral activity. It inhibits HIV-1 protease in vitro with an IC50 value of 161 µM. Stachybotrylactam has no effect on oleic acid-elicited intracellular lipid accumulation and has no observable cytotoxicity at concentrations up to 100 µM in HepG2 cells.Formal Name: (1'R,2'R,4'aS,6'R,8'aS)-3',4',4'a,5',6',7,7',8,8',8'a-decahydro-4,6'-dihydroxy-2',5',5',8'a-tetramethyl-spiro[2H-furo[2,3-e]isoindole-2,1'(2'H)-naphthalen]-6(3H)-one. CAS Number: 163391-76-2. Molecular Formula: C23H31NO4. Formula Weight: 385.5. Purity: >95%. Formulation: (Request formulation change), A lyophilisate. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. lambdamax: 219 nm. SMILES: O=C1NCC2=C1C=C(O)C3=C2O[C@]4([C@](CC[C@@H](O)C5(C)C)(C)[C@@]5([H])CC[C@H]4C)C3. InChi Code: InChI=1S/C23H31NO4/c1-12-5-6-17-21(2,3)18(26)7-8-22(17,4)23(12)10-14-16(25)9-13-15(19(14)28-23)11-24-20(13)27/h9,12,17-18,25-26H,5-8,10-11H2,1-4H3,(H,24,27)/t12-,17+,18-,22+,23-/m1/s1. InChi Key: ZSVLMDBFFSSVAK-RCJATNNHSA-N.