ST1936

ST1936 is an agonist of the serotonin (5-HT) receptor subtype 5-HT6. It selectively binds to 5-HT6 (Ki = 31 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, and the serotonin transporter (SERT, Kis = >1,000 nM for all) but also binds to the 5-HT7 receptor (Ki = 168 nM). ST1936 induces cAMP accumulation in BHK fibroblasts (EC50 = 16 nM). It decreases the basal firing rate of dopaminergic neurons in the ventral tegmental area but not substantia nigra pars compacta in rats in a dose-dependent manner. ST1936 (10 and 30 mg/kg) prevents stress-induced decreases in vanilla sugar-sustained appetitive behavior, indicating anti-anhedonic-like activity, in rats. It induces self-administration in rats when administered at a dose of 1 mg/kg.Formal Name: 5-chloro-N,N,2-trimethyl-1H-indole-3-ethanamine. CAS Number: 1210-81-7. Molecular Formula: C13H17ClN2. Formula Weight: 236.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble. SMILES: ClC1=CC=C2C(C(CCN(C)C)=C(C)N2)=C1. InChi Code: InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3. InChi Key: KSYMELKKLOFABL-UHFFFAOYSA-N.