SRS11-92

SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1 (Cay-17729). It inhibits ferroptotic cell death induced by erastin (Cay-17754) in HT-1080 human fibrosarcoma cells (EC50 = 6 nM). SRS11-92 (2 µM) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM. It also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington's disease in a concentration-dependent manner. SRS11-92 (3 µM) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner. It is selectively toxic to L. major promastigotes (LD50 = 3.34 µM) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 µM.Formal Name: 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-benzoic acid, ethyl ester. CAS Number: 1467047-25-1. Synonyms: AA9. Molecular Formula: C22H28N2O2. Formula Weight: 352.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 250, 298, 323 nm. SMILES: O=C(OCC)C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3. InChi Code: InChI=1S/C22H28N2O2/c1-2-26-22(25)18-13-14-20(24-19-11-7-4-8-12-19)21(15-18)23-16-17-9-5-3-6-10-17/h3,5-6,9-10,13-15,19,23-24H,2,4,7-8,11-12,16H2,1H3. InChi Key: VHQAJFNLPQULSV-UHFFFAOYSA-N.