Spiromesifen

Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase. It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC50s = 0.60 and 0.72 µM for enzyme isolated from lab and field strains, respectively). It induces toxicity in whitefly (T. vaporariorum) nymphs (LC50 = 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC50 = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC50s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application). Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pests H. armigera, O. nubilalis, and P. xylostella, respectively, and induces 100% mortality in M. separata when used at a dose of 100 mg/kg. It induces toxicity in D. magna (EC50 = >0.092 mg a.s./L) and the fish species O. mykiss and L. macrochirus (LC50s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD50 = >2,000 mg/kg). Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC50 = 12.1 µM). Formulations containing spiromesifen have been used as insecticides and miticides in agriculture, as well as commercial, industrial, and residential areas.Formal Name: 3,3-dimethyl-butanoic acid, 2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl ester. CAS Number: 283594-90-1. Molecular Formula: C23H30O4. Formula Weight: 370.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CC1=C(C2=C(OC(CC(C)(C)C)=O)C3(CCCC3)OC2=O)C(C)=CC(C)=C1. InChi Code: InChI=1S/C23H30O4/c1-14-11-15(2)18(16(3)12-14)19-20(26-17(24)13-22(4,5)6)23(27-21(19)25)9-7-8-10-23/h11-12H,7-10,13H2,1-6H3. InChi Key: GOLXNESZZPUPJE-UHFFFAOYSA-N.