Specnuezhenide

Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities. It reduces neurotoxicity induced by 6-OHDA (Cay-25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 µM. Specneuzhenide (25, 50, and 100 µM) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells. It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells. Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1alpha, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells. In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.Formal Name: 2-(4-hydroxyphenyl)ethyl, 6-[(2S,3Z,4S)-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate], beta-D-glucopyranoside. CAS Number: 449733-84-0. Synonyms: 8(Z)-Nuzhenide. Molecular Formula: C31H42O17. Formula Weight: 686.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 14 mg/ml, Ethanol: 17 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 227 nm. SMILES: OC[C@H]1O[C@](O[C@@H]2OC=C(C(OC)=O)[C@@H](CC(OC[C@H]3O[C@@H](OCCC4=CC=C(O)C=C4)[C@H](O)[C@@H](O)[C@@H]3O)=O)/C2=C/C)([H])[C@H](O)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C31H42O17/c1-3-16-17(18(28(41)42-2)12-45-29(16)48-31-27(40)24(37)22(35)19(11-32)46-31)10-21(34)44-13-20-23(36)25(38)26(39)30(47-20)43-9-8-14-4-6-15(33)7-5-14/h3-7,12,17,19-20,22-27,29-33,35-40H,8-11,13H2,1-2H3/b16-3-/t17-,19+,20+,22+,23+,24-,25-,26+,27+,29-,30+,31-/m0/s1. InChi Key: STKUCSFEBXPTAY-GSUVRYNNSA-N. Origin: Plant/Ligustrum lucidum.