Sordarin (sodium salt)

Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa. It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 µM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 µg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 µg/ml). It inhibits the growth of C. albicans (MIC = 8 µg/ml) but not C. glabrata or C. neoformans (MICs = >125 µg/ml).Formal Name: (1R,3aR,4S,4aR,7R,7aR,8aS)-8a-[[(6-deoxy-4-O-methyl-beta-D-altropyranosyl)oxy]methyl]-4-formyl-4,4a,5,6,7,7a,8,8a-octahydro-7-methyl-3-(1-methylethyl)-1,4-methano-s-indacene-3a(1H)-carboxylic acid, monosodium salt. CAS Number: 463356-00-5. Molecular Formula: C27H39O8 . Na. Formula Weight: 514.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: C[C@H]1O[C@@H](OC[C@@]23[C@@](C(C(C)C)=C[C@@]3([H])C4)(C([O-])=O)[C@@]4(C=O)[C@@]5([H])[C@]([C@H](C)CC5)([H])C2)[C@@H](O)[C@H](O)[C@@H]1OC.[Na+]. InChi Code: InChI=1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23,/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32),/q,+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+,/m1./s1. InChi Key: ILUKWKGTAAZHDW-IGICPMPSSA-M.