SN-6

An NCX1 inhibitor (IC50 = 2.9 µM), selective for NCX1 over NCX2, NCX3, and NCKX2 (IC50s = 16, 8.6, and >30 µM, respectively) and a panel of 26 additional ion channels and receptors at 30 µM, inhibits bidirectional inward and outward currents and unidirectional outward currents in whole-cell voltage-clamp assays using isolated guinea pig ventricular myocytes (IC50s = 1.9, 2.3, and 0.6 µM, respectively), reduces hypoxia-reoxygenation-induced LDH release in LLC-PK1 cells overexpressing NCX1 (IC50 = 0.63 µM), decreases ethanol intake and preference in female rats at 10 mg/kg, decreases the incidence of clonic and tonic-clonic seizures induced by PTZ in rats from 1-30 mg/kg. Formulation: A solid. InChI: InChI=1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3. InChIKey: ZVYIJXLMBWCGHP-UHFFFAOYSA-N. SMILES: O=C(OCC)C(N1)CSC1CC(C=C2)=CC=C2OCC(C=C3)=CC=C3[N+]([O-])=O