(-)-Sinoacutine

(-)-Sinoacutine is an alkaloid that has been found in S. acutum and has cytoprotective and vasorelaxant activities. It inhibits hydrogen peroxide-induced decreases in viability in PC12 cells when used at concentrations of 1 and 10 µM. (-)-Sinoacutine induces relaxation of precontracted isolated rat aortic rings (IC50 = 32.8 µM).Formal Name: (9alpha,13alpha)-5,6,8,14-tetradehydro-4-hydroxy-3,6-dimethoxy-17-methyl-morphinan-7-one. CAS Number: 4090-18-0. Synonyms: (-)-Salutaridine. Molecular Formula: C19H21NO4. Formula Weight: 327.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:4): 0.2mg/mL, DMSO: 5mg/mL, Ethanol: 1mg/mL. lambdamax: 241 nm. SMILES: COC1=C[C@@]2(C3=C(O)C(OC)=CC=C3C[C@@H]4N(C)CC2)C4=CC1=O. InChi Code: InChI=1S/C19H21NO4/c1-20-7-6-19-10-16(24-3)14(21)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9-10,13,22H,6-8H2,1-3H3/t13-,19+/m0/s1. InChi Key: GVTRUVGBZQJVTF-ORAYPTAESA-N. Origin: Plant/Sinomenii caulis.