Sinapinic Acid

Description: Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-kappaB p65 activation and proinflammatory cytokine expression. Sinapic acid with antioxidant role protects cardiac cells and its functions from I/R induced oxidative stress. Sinapic acid is a potentially useful agent for the protection against liver fibrosis and cirrhosis. Sinapic acid prevents the alterations in the levels of lipids and lipoproteins by virtue of its anti-lipidaemic effect in isoproterenol induced myocardial infarcted rats. Sinapic acid ameliorates hyperglycemia through PLC-PKC signals to enhance the glucose utilization in diabetic rats. Target: Apoptosis, HDAC, RAAS, Reactive Oxygen Species. Smiles: O(C)C1=C(O)C(OC)=CC(C=CC(O)=O)=C1. References: Cherng YG,et al.Antihyperglycemic action of sinapic acid in diabetic rats. 2013 Dec 11,61(49):12053-9.