SIM1 | TargetMol | Biomol.com

Please request pricing for this article.
Request Pricing

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T41226-5mg	5 mg				7 - 10 business days*		-

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Description: SIM1 is a potent and selective trivalent PROTAC(R)Degrader based on BET bromodomain... more

Close menu

Product information "SIM1"

Description: SIM1 is a potent and selective trivalent PROTAC(R)Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively). SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader. SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells. Target: PROTACs. References: Imaide et al (2021) Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity Nat.Chem.Biol. 17 1157 PMID: 34675414

Supplier:	TargetMol
Supplier-Nr:	T41226

Properties

Database Information

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

Information about the product reference will follow. more

Close menu

You will get a certificate here

Go back

Read, write and discuss reviews... more

Close menu

Customer review for "SIM1"

Write a review