Shogaol

Colourless to yellow liquid. Soluble in DMSO (10mg/ml). Chemical. CAS: 555-66-8. Formula: C17H24O3. MW: 276.37. Shogaol is a pungent bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory, anticancer, antioxidant, neuroprotective, antidiabetic, cardioprotective and antimicrobial properties. The anticancer activity is associated with the induction of apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairment of tubulin polymerization, downregulation of STAT3 and NF-kappaB signaling, inhibition of the expression of inflammatory mediators and suppresseion of Toll-like receptor signaling. It also has been shown to induce autophagy and activate peroxisomal proliferator activated receptor gamma (PPARgamma). 6-Shogaol can also activate both TRPV1 and TRPA1 channels. 6-Shogaol inhibits the NF-kappaB and NLRP3 signaling pathways.