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Description: SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 µM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4. Target: TRP/TRPV Channel. Smiles: CCCN(C)c1cc(nc(SCCC(=O)NCc2ccco2)n1)C(F)(F)F. References: Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14,62(3):1373-1384.
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