Seneciphylline

Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites. It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner. Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM). Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila. Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.Formal Name: (3Z,6R,14aR,14bR)-3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione. CAS Number: 480-81-9. Synonyms: NSC 30622. Molecular Formula: C18H23NO5. Formula Weight: 333.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 212 nm. SMILES: O=C(/C(CC([C@@]1(C)O)=C)=C\C)O[C@]2([H])CCN3[C@]2([H])C(COC1=O)=CC3. InChi Code: InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4-/t14-,15-,18-/m1/s1. InChi Key: FCEVNJIUIMLVML-QPSVUOIXSA-N. Origin: Plant/Senecio scandens Buch.-Ham..