Semax

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) (Cay-27106) that has neuroprotective, analgesic, and anxiolytic properties. In vivo, semax (0.3 mg/kg) reduces cortical nitric oxide (NO) production and the number of neurological disturbances, such as seizures, falling, and twisting, in a rat model of global ischemia. It decreases acetic acid-induced writhing and nociception in a hind paw compression test in mice when administered at doses ranging from 0.015 to 0.5 mg/kg. Semax also increases time spent in the open arms in the elevated plus maze, indicating anxiolytic activity, in a rat model of maternal deprivation-induced anxiety.Formal Name: L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline. CAS Number: 80714-61-0. Synonyms: ACTH4-7-PGP. Molecular Formula: C37H51N9O10S. Formula Weight: 813.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC([C@H]1N(C(CNC([C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCSC)=O)CCC(O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCC2)=O)=O)CCC1)=O. InChi Code: InChI=1S/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26-,27-,28-,29-/m0/s1. InChi Key: AFEHBIGDWIGTEH-AQRCPPRCSA-N.