SEA0400

SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively). It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.Formal Name: 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxy-benzenamine. CAS Number: 223104-29-8. Molecular Formula: C21H19F2NO3. Formula Weight: 371.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/mL, DMSO: 2 mg/mL, Ethanol: 0.25 mg/mL. lambdamax: 288 nm. SMILES: NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2. InChi Code: InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3. InChi Key: YSUBLPUJDOWYDP-UHFFFAOYSA-N.