SCH772984 HCl

Description: SCH772984 HCl is a selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors, with IC50s of 4 and 1 nM, respectively. SCH772984 HCl has nanomolar cellular potency in tumor cells with mutations in BRAF, NRAS, or KRA. Target: Others, ERK. Smiles: O=C(NC1=CC2=C(NN=C2C3=CC=NC=C3)C=C1)[C@H]4CN(CC(N5CCN(C6=CC=C(C7=NC=CC=N7)C=C6)CC5)=O)CC4.[H]Cl. References: Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul,3(7):742-50.