SBI-425

SBI-425 is an inhibitor of tissue-nonspecific alkaline phosphatase (TNAP, IC50 = 0.016 µM). It is selective for TNAP over a panel of 35 targets at 10 µM. SB-425 (10 and 30 mg/kg) increases survival and nearly completely inhibits the development of medial arterial calcification in a mouse model of chronic kidney disease-mineral bone disorder (CKD-MBD) induced by a high-adenine high-phosphate diet.Formal Name: 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-3-pyridinecarboxamide. CAS Number: 1451272-71-1. Molecular Formula: C13H12ClN3O4S. Formula Weight: 341.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N. InChi Code: InChI=1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18). InChi Key: SBAITEDLNTYIOE-UHFFFAOYSA-N.