SB297006
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3, IC50 = 39 nM), which... more
Product information "SB297006"
Description: SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3, IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1delta. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg). Target: CCR. Smiles: CCOC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1ccccc1. References: Mori, A., Ogawa, K., Someya, K., et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int. Immunol. 19(8), 913-921 (2007).
| Keywords: | SB 297006 |
| Supplier: | TargetMol |
| Supplier-Nr: | T4674 |
Properties
| Application: | CCR3 antagonist |
| MW: | 342.35 D |
| Formula: | C18H18N2O5 |
Database Information
| CAS : | 58816-69-6| Matching products |
| KEGG ID : | K04178 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H400 |
| P Phrases: | P264, P270, P273, P330, P391, P301+P310, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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