SB-699551 (hydrochloride)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
SB-699551 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT5A (Ki = 6. nM). It is... more
Product information "SB-699551 (hydrochloride)"
SB-699551 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT5A (Ki = 6. nM). It is selective for 5-HT5A over a panel of 14 other receptors (Kis = >315 nM for all) but does inhibit the serotonin transporter (SERT, Ki = 25. nM). SB-699551 also decreases sphere formation in patient-derived xenograft (PDX) breast cancer cells (IC50 = 596 nM). It decreases tumor volume in combination with docetaxel (Cay-11637) in a PDX mouse model of breast cancer. SB-699551 inhibits cued fear conditioning in mice (ED50 = 25. mg/kg).. Solulibility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml: DMSO: Soluble: =10 mg/ml, Water: Slightly soluble: 0.1-1 mg/ml.
| Keywords: | 3-cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide, hydrochloride |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 42517 |
Properties
| Application: | 5-HT5A antagonist |
| MW: | 511.75 D |
| Formula: | C34H45N3O . XHCl |
| Purity: | >95% |
| Format: | Solid |
Database Information
| KEGG ID : | K04161 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P301+310, P330, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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